Cerium Oxide Nanoparticles Regulate Osteoclast Differentiation Bidirectionally by Modulating the Cellular Production of Reactive Oxygen Species.

Int J Nanomedicine · 2020 · PMC7457858 · PMID 32922006

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a decreasing trendno p-value reported

The pH of BMMs on day 2 showed a decreasing trend when the concentrations of CeO 2 NPs increased from 0 to 8 mg/L and then steadily rose when concentrations of CeO 2 NPs increased from 16 to 64 mg/L.

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an increasing trendno p-value reported

We also measured the downstream genes that are regulated by Nfatc1, including Acp5 , Ctsk , DCSTAMP , Traf6 , C-Fos , and Calcr , and showed an increasing trend in the expression of these genes in the lower CeO 2 NP concentration groups (4,8 mg/L) and a decreasing trend in expression in the higher CeO 2 NP concentration group.

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