Vaccination Prevented Short-Term Memory Loss, but Deteriorated Long-Term Spatial Memory in Alzheimer's Disease Mice, Independent of Amyloid-β Pathology.

Whereas for all mice no associations were observed for microglia activity and behavioral performance, when focusing on only the 12-month-old vaccinated mice and their mock controls, a highly significant correlation was seen between hippocampal microglia activity and AUC of the MWM learning curve ( r = 0.78, p = 0.008), which could completely be attributed to microglia activity in the Hilus ( r = 0.93, p < 0.000).

also in 132,142 other papers