The anti-proliferative activity of SFE was further determined using the colony formation assay, which demonstrated a decreasing trend of relative colony formation rates of cancer cells as the SFE concentration increased gradually (Fig. 1c ).
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Sulforaphene inhibits esophageal cancer progression via suppressing SCD and CDH3 expression, and activating the GADD45B-MAP2K3-p38-p53 feedback loop.
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