Our interpretation of the absence of significant correlations of single GB methylation levels with OS but a highly significant summarized GB methylation measure (i.e., the ratio of high/low methylated to intermediate methylated GBs, described here as MDF and MUMF) is that this measure indicates a malignant epigenetic phenotype dysregulating the whole transcriptional process in the cell but not tumor suppressor genes or oncogenes predominantly.
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A Global Gene Body Methylation Measure Correlates Independently with Overall Survival in Solid Cancer Types.
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