In both Tyro3- and Axl-knockout mixed glial cells, Gas6 was no longer able to alter IL-10 expression, whereas in Mer-knockout cells, Gas6-induced IL-10 upregulation was observed to be at about the same level as in wildtype cells, close to significance ( Figure 3 C).
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Gas6 Induces Myelination through Anti-Inflammatory IL-10 and TGF-β Upregulation in White Matter and Glia.
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