highly significantP < .01
30 In the reconstituted OPLS‐DA loading plots, red, orange, and blue colors represent the metabolites with highly significant statistical difference ( P < .01 and VIP > 1), significant statistical difference (0.01 ≤ P < .05 and VIP > 1), and no significant statistical difference ( P ≥ .05 or VIP < 1), respectively. 2.8.