Cocaine potently blocks neuronal α₃β₄ nicotinic acetylcholine receptors in SH-SY5Y cells.

Unpaired t -test analysis for each nicotine concentration pair with 1.5 μM cocaine showed highly significant differences between nicotine alone and nicotine plus cocaine at all tested nicotine concentrations, including 10 (inhibitory rate = 40.8% ± 12.6%), 100 (inhibitory rate = 40.8% ± 7.7%) and 1000 μM (inhibitory rate = 35.8% ± 4.2%, Fig. 2c , black circle symbols).

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