<i>Nigella sativa</i> and <i>Trigonella foenum-graecum</i> Supplemented Chapatis Safely Improve HbA1c, Body Weight, Waist Circumference, Blood Lipids, and Fatty Liver in Overweight and Diabetic Subjects: A Twelve-Week Safety and Efficacy Study.

These authors conclude, “...small, highly significant reductions in total and LDL cholesterol, equivalent to ca. 6% LDL reduction, particularly when combined with other dietary measures, can make a useful contribution to blood cholesterol management.” The combined effects of encapsulated N. sativa and fenugreek on serum TG, HDL, and creatinine levels were evaluated in T2D patients with FBG >133 and HbA1c >7.0. 28 Using 1:1 combinations of 1000–2000 mg/day with glibenclamide the authors reported −1.17% ( P = .075) and +3.98% ( P = .013) changes in TG and HDL, respectively, in the treated group versus no changes in TG or HDL in the control group.

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