Barely Significant
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E1784K, the most common Brugada syndrome and long-QT syndrome type 3 mutant, disrupts sodium channel inactivation through two separate mechanisms.

J Gen Physiol · 2020 · PMC7478868 · PMID 32569350

Europe PMCDOI
1
hedged sentence
0.0772
closest p · 1.5× alpha
0.0772
boldest claim

The sentences

a nonsignificant trendP = 0.0772so close (0.05 < p ≤ 0.1)
At pH 7.4, E1784K, E1784R, and E1784Q are shifted toward significantly more hyperpolarized membrane potentials compared with E1784E (P ≤ 0.0289 in all cases), whereas E1784V shows a nonsignificant trend (P = 0.0772; Fig. 2 A , inset).

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