In the present investigation, an increasing trend for the occurrence of isolates harboring psp A2 and PI-1 genes was observed over the years, in parallel with a decreasing tendency of isolates showing psp A1 genes and the opaque phenotype ( Figure 1 ).
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Virulence-Associated Characteristics of Serotype 14 and Serogroup 9 <i>Streptococcus pneumoniae</i> Clones Circulating in Brazil: Association of Penicillin Non-susceptibility With Transparent Colony Phenotype Variants.
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