2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) dysregulates hepatic one carbon metabolism during the progression of steatosis to steatohepatitis with fibrosis in mice.

Sci Rep · 2020 · PMC7481292 · PMID 32908189

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a decreasing trendno p-value reported

By 28 days, the SAM/SAH ratio exhibited a non-monotonic dose–response, with a decreasing trend between 0.3 and 10 μg/kg TCDD (Fig. 1 c).

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