Renin-Angiotensin System Inhibitors and COVID-19: a Systematic Review and Meta-Analysis. Evidence for Significant Geographical Disparities.

Curr Hypertens Rep · 2020 · PMC7481766 · PMID 32910274

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an observed trendno p-value reported

In our analysis, no significant differences were observed among ACE inhibitors and ARBs regarding odds for SARS-CoV-2-positive testing, ICU admission, and death, although there was an observed trend towards reduced odds for death with the use of ACE inhibitors.

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marginally insignificantno p-value reported

SARS-CoV-2-Related Death Of interest, ACE inhibitors were found to be superior to ARBs in SARS-CoV-2-related death, although the result is marginally insignificant (OR = 0.86, 95% CI 0.74–1.00, I 2 = 0%), as shown in Fig. 3c .

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