Impact of vaccination on invasive pneumococcal disease in Italy 2007-2017: surveillance challenges and epidemiological changes.

A decreasing trend in notification rate was observed among those aged 0–4 years.

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These regions reported a notification rate equal to or above the threshold of 1 per 100 000 population during the study period with an increasing trend: from 2.2 in 2007 to 3.7 in 2017 in Emilia Romagna, from 1.1 to 3.7 in Friuli Venezia Giulia, from 1.5 to 6.6 in Lombardy, from 1.3 to 8.7 in Trentino Alto Adige, from 2.2 to 2.7 in Veneto, from 1.0 to 7.1 in Piedmont.

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