Resolution of R-loops by INO80 promotes DNA replication and maintains cancer cell proliferation and viability.

Partial correlation analysis performed on the INO80 ChIP-seq and DRIP-seq data over RNA-seq data, indicated that the correlation between INO80 and R-loop enrichments remained highly significant when controlled for gene expression levels ( p = 5.5 × 10 −160 , Supplementary Fig. 10a–c ).

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