Split Thickness Skin Graft of the Foot and Ankle Bolstered With Negative Pressure Wound Therapy in a Diabetic Population: The Results of a Retrospective Review and Review of the Literature.

Porcine experiment model with graft biopsies at days 2, 4, 6, 8, and 10 contradicts any difference in vascular ingrowth even though better subjective graft incorporation was noted in the NPWT samples and a nonsignificant trend toward improved graft survival in the NPWT group. 36 On a different animal model, NPWT appears to improve angiogenesis and blood circulation occurred by increasing capillary caliber and blood volume, while also decrease in edema by narrowing endothelial spaces resulting in decrease permeability. 37

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