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A randomized, double-blind, positive-controlled, prospective, dose-response clinical study to evaluate the efficacy and tolerability of an aqueous extract of Terminalia bellerica in lowering uric acid and creatinine levels in chronic kidney disease subjects with hyperuricemia.

BMC Complement Med Ther · 2020 · PMC7493401 · PMID 32933504

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a decreasing trendno p-value reported
Malondialdehyde had shown a decreasing trend in their study.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.