Host Porphobilinogen Deaminase Deficiency Confers Malaria Resistance in <i>Plasmodium chabaudi</i> but Not in <i>Plasmodium berghei</i> or <i>Plasmodium falciparum</i> During Intraerythrocytic Growth.

A modest but highly significant survival advantage was also observed for female heterozygotes ( p = 0.0016); 90% of these animals survived for at least 1 day longer than their wild-type littermates, although 12 of 13 heterozygous mice eventually succumbed ( Figure 2C ).

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