Biphasic Dose-Response of Components From <i>Coptis chinensis</i> on Feeding and Detoxification Enzymes of <i>Spodoptera litura</i> Larvae.

Effect of Representative Compounds in Coptis chinensis on CarE Activity The CarE activity in the midgut of S litura larvae was also determined after exposed to the representative compounds derived from C chinensis or vehicle for 48 hours. Interestingly, the effect of all these compounds on CarE activity exhibited biphasic dose responses with an increasing trend from 0.05 or 0.1 to 0.5 or 1 mg·g −1 and a decreasing trend from 1 or 5 to 10 mg·g −1 ( Figure 4A-E ).

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Furthermore, a similar biphasic dose–response of the antifeedant activity against S litura larvae was also observed for jateorhizine, palmatine, and obakunone in Coptis chinensis . Notably, the enzyme activities of glutathione-S-transferase and carboxyl esterase in S litura larvae affected by the different components (jateorhizine, palmatine, obakunone, berberine, and coptisine) of C chinensis also showed a biphasic dose–response with an increasing trend at low doses and a decreasing trend at high doses.

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