Sex-opposed inflammatory effects of 27-hydroxycholesterol are mediated via differences in estrogen signaling.

Similarly, when plasma 27HC levels were specifically compared with hepatic lobular inflammation in the same obese population, significantly lower plasma 27HC levels were observed in obese females suffering from hepatic lobular inflammation (Figure 1B and supplementary material, Figure S2B , left panel), while an increasing trend was found for plasma 27HC levels in obese males (Figure 1B and supplementary material, Figure S2B , right panel).

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