markedly significantP < 0.001
This association remained markedly significant in the multivariate Cox model after controlling for age, gender, clinical stage, and mismatch repair (MMR) status (HR, 0.41 [95% CI: 0.30–0.57], P < 0.001; Figure 2B ).
This association remained markedly significant in the multivariate Cox model after controlling for age, gender, clinical stage, and mismatch repair (MMR) status (HR, 0.41 [95% CI: 0.30–0.57], P < 0.001; Figure 2B ).
APC was the most common mutational gene in colorectal cancer, and its mutation has indicated a highly significant association with immune resistance ( 38 ).