Indeed, a highly significant negative correlation between nucleosome occupancy and probability of harboring a DSB was clearly present in MCF-7 cells either transfected with a control scrambled siRNA, or exposed to DMSO as control for a pharmacological treatment (Figure 5A ).
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Nucleosomes effectively shield DNA from radiation damage in living cells.
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The correlation was extremely significant and replicated with each dose of irradiation ( Supplementary Figure S4D ).