During this same time period, flow cytometric analyses of circulating white blood cells in the plasma revealed a gradual and stark decline of hCD45 cells in the HIV OPN + , which contrasted with the higher levels detected in the HIV OPN - group; however the differences in slopes were not quite significant (Fig. 1 c, F = 3.800.
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Osteopontin/secreted phosphoprotein-1 behaves as a molecular brake regulating the neuroinflammatory response to chronic viral infection.
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