Smoking and multiple sclerosis risk: a Mendelian randomization study.

In our data, genetically predicted MS risk was not associated with smoking initiation [OR = 1.00, 95% CI (0.99, 1.01), p = 0.96], or lifetime smoking [ β = 0.002, 95% CI (− 0.003, 0.007), p = 0.51], with a possible trend seen only for smoking heaviness [ β = 0.016, 95% CI (0.003, 0.028), p = 0.02].

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The IVW analysis of BMI and smoking initiation was highly significant and appeared bidirectional.

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