Asymmetric Conservation within Pairs of Co-Occurred Motifs Mediates Weak Direct Binding of Transcription Factors in ChIP-Seq Data.

However, only for HNF1β (HNF1B_MOUSE.H11MO.0.A, [ 14 ]) we found the extremely significant asymmetry within predicted CEs toward the partner motif ( p < 2 × 10 −28 and p < 4 × 10 −17 for CEs with an overlap of motifs and with a spacer, respectively).

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