Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samples.

We found a small but highly significant effect: each additional subclone increased the average absolute difference in VAF of the shared variants between MC3 and PCAWG by 0.003, with a p -value of 1.3 × 10 −11 (linear regression); this effect reversed after controlling for tumor purity, indicating that the observed trend does not provide evidence of this interesting concept in re-sequencing (see “Methods” section for details).

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