The impact of fremanezumab on medication overuse in patients with chronic migraine: subgroup analysis of the HALO CM study.

J Headache Pain · 2020 · PMC7507645 · PMID 32958075

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failed to reach significanceno p-value reported

Topiramate, a migraine preventive treatment, significantly reduced migraine days in patients with CM, but failed to reach significance in a post hoc analysis of patients with CM and MO, possibly due to a small sample size [ 21 ].

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