ctDNA Concentration, MIKI67 Mutations and Hyper-Progressive Disease Related Gene Mutations Are Prognostic Markers for Camrelizumab and Apatinib Combined Multiline Treatment in Advanced NSCLC.

Another concern is that due to the better response in patients with combined therapy, the effect of stratification by PD-L1 may not be significant anymore, and patients with negative PD-L1 expression may also benefit from the therapy, which was reflected in some recent studies ( 15 – 17 ).

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