Serum NT/CT SIRT1 ratio reflects early osteoarthritis and chondrosenescence.

Ann Rheum Dis · 2020 · PMC7509530 · PMID 32665267

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marginally significantno p-value reported

Assessing the same cohort with a sandwich ELISA method ( online supplementary S3B, C ) displayed significant increase for NT SIRT1 with OA severity, which was marginally significant for CT and NT/CT SIRT1 variants, the latter due to reduced sensitivity of the assay to CT SIRT1 variants.

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