marginal significancep = 0.061
We detected a significant association between PD patients with depression and severe constipation (grade 3) (OR 5.81; 95% CI 1.24–27.29, p = 0.026, adjusted for age and gender), but a marginal significance after being adjusted for age, gender and UPDRS part 3 (OR 4.46, 95% CI 0.93–21.33; p = 0.061).