Prolonged infection triggered by dormant Mycobacterium tuberculosis: Immune and inflammatory responses in lungs of genetically susceptible and resistant mice.

First, the difference in CFU counts between susceptible and resistant mice was highly significant throughout infection; in resistant animals, the numbers of mycobacteria in organs remained stable for 1.5 years ( Fig 1 ), and no deaths were registered.

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However, the most likely explanation of this discrepancy is purely technical: only three I/St mice in appreciable health condition were available at this time point, which strongly increased statistical straggling, resulting in P = 0.057, i.e., borderline significance. 4.

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