Ribosomal stalk proteins RPLP1 and RPLP2 promote biogenesis of flaviviral and cellular multi-pass transmembrane proteins.

The polarity score analysis of all expressed ORFs revealed a small but highly significant shift of ribosomes toward the 5′ end of ORFs when RPLP1/2 were depleted (mean of the differences = 0.013, P = 2.2 × 10 −16 ) ( Supplementary Figure S12A ).

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