Mitochondrial-nuclear coadaptation revealed through mtDNA replacements in Saccharomyces cerevisiae.

Highly significant mitonuclear interaction terms were observed in each condition (ANOVA on the random effect model y ij = μ ~ mt i + n j + (mt × n) ij + ε ij , P < 0.0001, Table S 4 ) and could explain 10.8 to 31.5% of the total phenotypic variances (Fig. 1 c, Table S 5 ).

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