Elevated MnSOD activity and an increasing trend of CuZnSOD or TSOD activity is considered as response of the organism to high levels of superoxide, while lowered activity of GPx could induce accumulation of reactive oxygen species (ROS) that could cause protein, lipid, and DNA damages ( 31 ).
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Circulating Brain-Derived Neurotrophic Factor, Antioxidant Enzymes Activities, and Mitochondrial DNA in Bipolar Disorder: An Exploratory Report.
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