extremely significantp≤0.001
highly significantp≤0.01
p-value≤0.0001 is considered as extremely significant (****), p≤0.001 as highly significant (***), p≤0.01 as very significant (**), p≤0.05 as significant (*), and p>0.05 as not significant (ns), respectively. 10.7554/eLife.58374.sa1 Decision letter Macleod Kay F Reviewing Editor University of Chicago United States In the interests of transparency, eLife publishes the most substantive revision requests and the accompanying author responses.