Haploinsufficiency of TANK-binding kinase 1 prepones age-associated neuroinflammatory changes without causing motor neuron degeneration in aged mice.

Statistical significance is reported by the P -value of the statistical test procedures and was assessed as significant (* P < 0.05), strongly significant (** P < 0.01) or highly significant (*** P < 0.001; **** P < 0.0001).

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Again, we could detect only a small trend towards more aggregates in the aged cohort, without any effect due to heterozygous Tbk1 deletion ( Fig. 3E–H ).

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quadriceps ) showed only a slight trend towards denervation at the higher age compared to the earlier time point ( Fig. 2E and F ), while a significant increase in partially or fully denervated motor endplates was found in distal muscles ( m. lumbricalis ) in old mice compared to young animals ( Fig. 2G and H ) consistent with age-related NMJ defects observed by a previous study ( Valdez et al. , 2012 ).

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