highly significantP < 0.0002
The analysis showed that the level of TMEM244 expression is negatively correlated with the square of the methylation level in the promoter region ( R = −0.4766), and this correlation is highly significant ( P < 0.0002) (Figure 4 ). 4 DISCUSSION In this study, we showed that methylation is a key regulatory mechanism of TMEM244 expression.