marginally significantP = 1.29 × 10 −7
rs1456315 was found to be marginally significant in the African American GWAS ( P = 1.29 × 10 −7 ). rs1456315 and rs72725879 are linked ( r 2 = 0.815) in the Japanese American GWAS population and have similar allele frequencies across East Asian populations while rs1456315 and rs72725879 are less linked ( r 2 = 0.448) in the African American GWAS population and have divergent allele frequencies across African populations ( Fig 2 ). r 2 values between SNPs were calculated using PLINK in each individual case-control study.