Protective role of mirtazapine in adult female Mecp2^+/- mice and patients with Rett syndrome.

In addition, when comparing delta values of both groups, we observed in MTZ-treated patients a highly significant reduction (i.e., clinical improvement) for both RCSS ( p < 0.0001, Mann-Whitney; Fig. 4 b) and MBAS values ( p < 0.0001, Mann-Whitney; Fig. 4 d) with respect to the untreated group.

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