ANGPTL8 has both endocrine and autocrine effects on substrate utilization.

As we have shown previously, inactivation of A8 has little impact on fasting levels of plasma TGs, cholesterol, and nonesterified fatty acids (NEFAs) ( Figure 5, A and B ) (although a modest, but marginally significant [ P = 0.05] reduction in mean TG levels was seen in the A8-KO mice when compared with WT animals).

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