Cardiac Electronic Devices: Future Directions and Challenges.

At 6-month follow-up, His-CRT resulted in QRS narrowing with a nonsignificant trend toward a higher rate of echocardiographic response (91% vs 54%, p =0.078) compared with BiV-CRT; however, there were no significant differences in mortality or cardiovascular hospitalization between the groups. 23 As such, large multicenter RCTs are necessary to evaluate the clinical efficacy of His-bundle pacing and also comparing His-CRT and BiV-CRT.

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