Effect of maternal preconceptional and pregnancy micronutrient interventions on children's DNA methylation: Findings from the EMPHASIS study.

For all 7 ESM1 CpGs, the combined G + E models suggest that intervention and mQTL (allelic) main effects are highly significant and similar in magnitude ( Supplemental Table 10 ). mQTLs may suggest regulatory pathways underlying reported GWAS signals for common diseases ( 47 ).

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This was the second-ranked region in DMRcate and also contained a borderline significant DMP (cg27655507; Table 3 , Figure 2B , and Figure 4 ).

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