No change in the consumption of thyroid hormones after starting low dose naltrexone (LDN): a quasi-experimental before-after study.

The difference-in-difference between LDN × 1 and LDN × 4+ for LT4 was not significant (6.2 DDD, 95% CI − 11.3 to 23.7, p = 0.313), but the dispensed cumulative DDD in LDN × 4+ LT4 dispensing after was almost significantly larger after starting LDN (19.8 DDD, 95% CI − 0.1 to 23.7, p = 0.060).

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The difference-in-difference between LDN × 1 and LDN × 4+ for LT4 was not significant (6.2 DDD, 95% CI − 11.3 to 23.7, p = 0.313), but the dispensed cumulative DDD in LDN × 4+ LT4 dispensing after was almost significantly larger after starting LDN (19.8 DDD, 95% CI − 0.1 to 23.7, p = 0.060). There were no differences in the number of users of neither T3 nor LT4, except for a 2.0% points borderline significant reduction in the number of LT4 users in the LDN × 2–3 group (Table 3 ).

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