The highly significant overlap between pirfenidone and the top-scoring proteins of the 5 entry point proteins of SARS-CoV-2 is however biased, because furin is in this set and it’s also a target of pirfenidone ( Fig 3 ).
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In-silico drug repurposing study predicts the combination of pirfenidone and melatonin as a promising candidate therapy to reduce SARS-CoV-2 infection progression and respiratory distress caused by cytokine storm.
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