The Metalloproteinase ADAMTS5 Is Expressed by Interstitial Inflammatory Cells in IgA Nephropathy and Is Proteolytically Active on the Kidney Matrix.

1D ), we noted a positive but NS correlation between ADAMTS5 staining and proteinuria ( r = +0.36; p = 0.12) and a marginally significant negative correlation with eGFR ( r = −0.46; p = 0.04) indicating that ADAMTS5 might be increased as kidney function declines in IgAN, causing reduction in glomerular filtration (eGFR) and increase in urine protein concentration ( Fig. 1D ).

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