Interleukin-6 trans-signaling is a candidate mechanism to drive progression of human DCCs during clinical latency.

The overlap between the respective differentially expressed genes was highly significant in almost all comparisons (Fig. 5c , Supplementary Fig. 3d , and Supplementary Table 6 ) and the observed expression fold changes were consistent with the notion that IL-6/HIL6 stimulation recruits progenitor populations from both more differentiated and more stem-like populations, with the dedifferentiation branch (MatLum → LumProg) being more consistent than differentiation (MaSC → LumProg).

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