A comparative study between effect of combined intravenous and nebulized amikacin versus intravenous amikacin alone in mechanically ventilated patients with ventilator-associated pneumonia (VAP)

They found that there was a highly significant reduction in creatinine clearance values before and after the end of treatment between both groups with a rate of reduction of 10 mL/min (0–27) in the nebulized group vs 16 mL/min (8–30) in the IV group ( p < 0.001) (Hassan et al., 2018 ).

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