Evaluation of neurofilament light chain in the cerebrospinal fluid and blood as a biomarker for neuronal damage in experimental pneumococcal meningitis.

The relative increase of NfL levels over time in infected animals was highly significant in both CSF ( p < 0.01) and in serum ( p < 0.0001), whereas those of mock-infected animals remained stable in both fluid compartments (Fig. 2 a, b).

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