House dust endotoxin, asthma and allergic sensitization through childhood into adolescence.

33 , 38 The inverse associations of early life living room floor dust endotoxin exposure with asthma until age 4 (statistically significant for concentrations, marginally statistically significant ( P < .1) for loads) are consistent with findings of previous European studies of preschool children aged 2 years 39 and 5 years, 10 albeit inconsistent with regard to the relevant exposure site (ie living room floor vs maternal or child's mattress).

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There were marginally significant ( P < .1) interactions between endotoxin and the TLR4 /rs2737190, TLR4 /rs11536889 and TLR4 /rs10759932 genotypes for asthma suggesting lower odds of asthma with higher mattress dust endotoxin levels among those with the GA TLR4 /rs2737190 genotype (Table S8 ) and GG TLR4 /rs11536889 and TC/CC TLR4 /rs10759932 genotypes (Table S9 ), respectively.

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