The levels of the inflammation markers IL-6 and the NLR showed an increasing trend during the following days after TCZ initiation in non-responders, and peaked several days afterwards; by contrast, they remained relatively stable in patients with favorable outcome.
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The same occurred with D-dimer, an independent predictor of hospital death in patients with COVID-19 26 , that reflects a pro-coagulant state and increased thrombotic risk associated with severe disease in COVID-19 27 , and which only showed a decreasing trend in patients responding to TCZ.