Colorectal Cancer Genetics, Incidence and Risk Factors: In Search for Targeted Therapies.

45 During the twenty-year period, the average age of diagnosis and death showed an increasing trend. 44 , 45 Since the 1970s, the CRC incidence rates have also increased in Shanghai. 46 The Jiashan county in the north of Zhejiang Province has the highest incidence of colon cancer in China. 47 Other risk factors that have been identified in China included the use of oral contraceptives, progesterone injections during pregnancy, induced abortions, 46 psychological depression, negative emotion and lower digestive tract diseases. 47 Colorectal Risk Factors CRC is considered to be one of the major cancers for which modifiable causes may be identified and prevented.

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